Demis Bellot has two excellent articles on using F# with ServiceStack:  F# Web Services on any platform in and out of a web server  Async, Cached Twitter API Proxy in F# To quote:  You now have a fully-fledged ServiceStack ASP.NET application that can be hosted in any ASP.NET compatible web server e.g: IIS Apache + mod_mono Nginx + MonoFastCGI XSP WebDevServer.exe Now that you know how to create functional F# web services, you can read more about the goodies you get for free when using Service Stack[...]